Heterotrimeric G proteins and apoptosis: intersecting signaling pathways leading to context dependent phenotypes.

@article{Yanamadala2009HeterotrimericGP,
  title={Heterotrimeric G proteins and apoptosis: intersecting signaling pathways leading to context dependent phenotypes.},
  author={Vijay Yanamadala and Hideyuki Negoro and Bradley M Denker},
  journal={Current molecular medicine},
  year={2009},
  volume={9 5},
  pages={527-45}
}
Apoptosis, a programmed cell death mechanism, is a fundamental process during the normal development and somatic maintenance of all multicellular organisms and thus is highly conserved and tightly regulated through numerous signaling pathways. Apoptosis is of particular clinical importance as its dysregulation contributes significantly to numerous human diseases, primarily through changes in the expression and activation of key apoptotic regulators. Each of the four families of heterotrimeric G… CONTINUE READING

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