Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time.

@article{Aznar2016HeterotrimericGP,
  title={Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time.},
  author={Nicolas Aznar and Nicholas A. Kalogriopoulos and Krishna K. Midde and Pradipta Ghosh},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2016},
  volume={38 4},
  pages={379-93}
}
Canonical signal transduction via heterotrimeric G proteins is spatially and temporally restricted, that is, triggered exclusively at the plasma membrane (PM), only by agonist activation of G protein-coupled receptors (GPCRs) via a process that completes within a few hundred milliseconds. Recently, a rapidly emerging paradigm has revealed a non-canonical pathway for activation of heterotrimeric G proteins by the non-receptor guanidine-nucleotide exchange factor (GEF), GIV/Girdin. This pathway… CONTINUE READING
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