Heterotrimeric G protein activation by G-protein-coupled receptors

@article{Oldham2008HeterotrimericGP,
  title={Heterotrimeric G protein activation by G-protein-coupled receptors},
  author={W. Oldham and H. Hamm},
  journal={Nature Reviews Molecular Cell Biology},
  year={2008},
  volume={9},
  pages={60-71}
}
  • W. Oldham, H. Hamm
  • Published 2008
  • Chemistry, Medicine
  • Nature Reviews Molecular Cell Biology
Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP–GDP exchange on the G protein α-subunit. The complex series of interactions and conformational changes that connect agonist binding to G protein activation raise various interesting questions about the structure, biomechanics, kinetics and specificity of signal transduction across the… Expand
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