Heterotrimer formation, together with isoprenylation, is required for plasma membrane targeting of Gbetagamma.

@article{Takida2003HeterotrimerFT,
  title={Heterotrimer formation, together with isoprenylation, is required for plasma membrane targeting of Gbetagamma.},
  author={Satoshi Takida and Philip B Wedegaertner},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 19},
  pages={
          17284-90
        }
}
Nascent beta and gamma subunits of heterotrimeric G proteins need to be targeted to the cytoplasmic face of the plasma membrane (PM) in order to transmit signals. We show that beta(1)gamma(2) is poorly targeted to the PM and predominantly localized to endoplasmic reticulum (ER) membranes when expressed in HEK293 cells, but co-expression of a G protein alpha subunit allows strong PM localization of the beta(1)gamma(2). Furthermore, C-terminal isoprenylation of the gamma subunit is necessary but… CONTINUE READING

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