Heterotransplantation of human breast carcinomas in nude mice. Correlation between successful heterotransplants, poor prognosis and amplification of the HER-2/neu oncogene.

@article{Giovanella1991HeterotransplantationOH,
  title={Heterotransplantation of human breast carcinomas in nude mice. Correlation between successful heterotransplants, poor prognosis and amplification of the HER-2/neu oncogene.},
  author={Beppino C. Giovanella and Dana M Vardeman and Lawrence G. Williams and D. J. E. Taylor and Peter D de Ipolyi and P J Greeff and John S. Stehlin and Axel Ullrich and Relda Cailleau and Dennis J. Slamon},
  journal={International journal of cancer},
  year={1991},
  volume={47 1},
  pages={66-71}
}
Four hundred and thirty-three human breast carcinomas and 23 cell lines derived from human breast carcinomas were heterotransplanted in nude mice. Twenty-eight tumors and 13 cell lines took and could be serially transplanted. Their human origin was established by isozyme analysis performed on successive passages. Sixteen primary infiltrating duct-cell carcinomas (PIDC) took, from a total of 262 transplanted (6.1%). This is in striking contrast to the greater than 50% rate of takes of most major… CONTINUE READING

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