Heterotopic osteogenesis in porous ceramics induced by marrow cells.

@article{Ohgushi1989HeterotopicOI,
  title={Heterotopic osteogenesis in porous ceramics induced by marrow cells.},
  author={Hajime Ohgushi and Victor M. Goldberg and Arnold I Caplan},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={1989},
  volume={7 4},
  pages={568-78}
}
When untreated porous calcium phosphate ceramics were transplanted into subcutaneous (s.c.) or intramuscular (i.m.) sites, fibrovascular tissue grew in the pore region without evidence of bone formation. However, when these same ceramics were combined with syngeneic marrow cells, osteogenesis was observed inside the pore region of the implanted ceramic. The osteogenesis began on the surface of the pore region at approximately 3 weeks postimplantation by a process of intramembranous bone… CONTINUE READING

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