Heterotopic Bone Formation Induced by Bone Morphogenetic Protein Signaling: Fibrodysplasia Ossificans Progressiva

@inproceedings{Katagiri2010HeterotopicBF,
  title={Heterotopic Bone Formation Induced by Bone Morphogenetic Protein Signaling: Fibrodysplasia Ossificans Progressiva},
  author={Takenobu Katagiri},
  year={2010}
}
Abstract Bone morphogenetic proteins (BMPs) were originally identified via their unique activity in demineralized bone matrix—they induce heterotopic bone formation in skeletal muscle. BMP activity is transduced by two types of BMP-specific transmembrane serine/threonine kinase receptors and downstream transcription factors, known as Smads. Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder characterized by progressive heterotopic bone formation in skeletal muscle… CONTINUE READING

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