Heterotaxy-spectrum heart defects in Zic3 hypomorphic mice

@article{Haaning2013HeterotaxyspectrumHD,
  title={Heterotaxy-spectrum heart defects in Zic3 hypomorphic mice},
  author={Allison M. Haaning and M. Quinn and S. Ware},
  journal={Pediatric research},
  year={2013},
  volume={74},
  pages={494 - 502}
}
Background:Mutations in Zinc Finger Protein of the Cerebellum 3 (ZIC3) cause X-linked heterotaxy and isolated cardiovascular malformations. Recent data suggest a potential cell-autonomous role for Zic3 in myocardium via regulation of Nppa and Tbx5. We sought to develop a hypomorphic Zic3 mouse to model human heterotaxy and investigate developmental mechanisms underlying variability in cardiac phenotypes.Methods:Zic3 hypomorphic mice were created by targeted insertion of a neomycin cassette and… Expand
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