Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine.

@article{Corti2010HeterosubtypicNA,
  title={Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine.},
  author={Davide Corti and Amorsolo L. Suguitan and Debora Pinna and Chiara Silacci and Blanca Maria Fernandez-Rodriguez and Fabrizia Vanzetta and C{\'e}lia Santos and Catherine J. Luke and Fernando J Torres-V{\'e}lez and Nigel J Temperton and Robin A Weiss and Federica Sallusto and Kanta Subbarao and Antonio Lanzavecchia},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 5},
  pages={1663-73}
}
The target of neutralizing antibodies that protect against influenza virus infection is the viral protein HA. Genetic and antigenic variation in HA has been used to classify influenza viruses into subtypes (H1-H16). The neutralizing antibody response to influenza virus is thought to be specific for a few antigenically related isolates within a given subtype. However, while heterosubtypic antibodies capable of neutralizing multiple influenza virus subtypes have been recently isolated from phage… CONTINUE READING
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Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

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