Heterospecific cytotoxic cell activity induced during the first three days of acute lymphocytic choriomeningitis virus infection in mice

@article{Welsh1977HeterospecificCC,
  title={Heterospecific cytotoxic cell activity induced during the first three days of acute lymphocytic choriomeningitis virus infection in mice},
  author={Raymond M. Welsh and Rolf Martin Zinkernagel},
  journal={Nature},
  year={1977},
  volume={268},
  pages={646-648}
}
ACUTE infection of adult mice with lymphocytic choriomeningitis virus (LCMV) induces several types of immune responses. H–2-restricted virus-specific cytotoxic T cells are demonstratable from day 5 to 6 and peak on day 7 to 10 post-infection1–5. Antiviral antibody in immune complexes is first detected by 4 d post infection6,7, and non-specifically activated macrophages can be demonstrated after 4 to 5 d (refs 3 and 8). We report here that the acute LCMV infection elicits the production or… CONTINUE READING

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