Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer’s Disease

  title={Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer’s Disease},
  author={Mar Rodr{\'i}guez-Ruiz and Estefan{\'i}a Moreno and David Moreno-Delgado and Gemma Navarro and Josefa Mallol and Antonio Cortés and Carmen Lluis and Enric I. Canela and Vicent Casad{\'o} and Peter J. McCormick and Rafael Franco},
  journal={Molecular Neurobiology},
Alzheimer’s disease (AD) is a neurodegenerative disorder causing progressive memory loss and cognitive dysfunction. Anti-AD strategies targeting cell receptors consider them as isolated units. However, many cell surface receptors cooperate and physically contact each other forming complexes having different biochemical properties than individual receptors. We here report the discovery of dopamine D1, histamine H3, and N-methyl-D-aspartate (NMDA) glutamate receptor heteromers in heterologous… 

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