Heteropoda toxin 2 is a gating modifier toxin specific for voltage-gated K+ channels of the Kv4 family.

@article{Zarayskiy2005HeteropodaT2,
  title={Heteropoda toxin 2 is a gating modifier toxin specific for voltage-gated K+ channels of the Kv4 family.},
  author={Vladislav V. Zarayskiy and Ganesh Balasubramanian and Vladimir E. Bondarenko and Michael S. Morales},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2005},
  volume={45 4},
  pages={431-42}
}
Kv4 voltage-gated K(+) channels are responsible for transient K(+) currents in the central nervous system and in the heart. HpTx2 is a peptide toxin that selectively inhibits these currents; making it a useful probe for understanding Kv4 channel structure and drug binding. Therefore, we developed a method to produce large amounts of recombinant HpTx2. Recombinant toxin inhibits all three Kv4 isoforms to the same degree; however, the voltage-dependence of inhibition is less apparent for Kv4.1… CONTINUE READING