Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium.

@article{Hundelshausen2004HeterophilicIO,
  title={Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium.},
  author={Philipp von Hundelshausen and Rory R Koenen and Markus Sack and Sebastian F. Mause and W Wencke Adriaens and Amanda E. I. Proudfoot and Tilman M. Hackeng and Christian Weber},
  journal={Blood},
  year={2004},
  volume={105 3},
  pages={
          924-30
        }
}
The chemokines platelet factor 4 (PF4) and RANTES (regulated on activation normal T cell expressed and secreted) are secreted by activated platelets and influence multiple cell types and biologic processes. For instance, PF4 inhibits progenitor cell proliferation and angiogenesis, while platelet-derived RANTES is involved in vascular recruitment of monocytes. However, little is known about functional interactions of PF4 and RANTES. Here we show that the presence of PF4 enhanced the arrest of… CONTINUE READING

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