Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus

@article{Basu2017HeterophilicTI,
  title={Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus},
  author={Raunak Basu and Xin Duan and Matthew R. Taylor and E Anne Martin and Shruti Muralidhar and Yueqi Wang and Luke Gangi-Wellman and Sujan C. Das and Masahito Yamagata and Peter J West and Joshua R Sanes and Megan E Williams},
  journal={Neuron},
  year={2017},
  volume={96},
  pages={160-176.e8}
}
Hippocampal CA3 neurons form synapses with CA1 neurons in two layers, stratum oriens (SO) and stratum radiatum (SR). Each layer develops unique synaptic properties but molecular mechanisms that mediate these differences are unknown. Here, we show that SO synapses normally have significantly more mushroom spines and higher-magnitude long-term potentiation (LTP) than SR synapses. Further, we discovered that these differences require the Type II classic cadherins, cadherins-6, -9, and -10. Though… CONTINUE READING

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