Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset.

@article{Orbn2001HeterophileAI,
  title={Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset.},
  author={Tiham{\'e}r Orb{\'a}n and Sally C. Kent and Poonam R. Malik and John David Milner and Katja Schuster and Richard Alan Jackson and David A. Hafler},
  journal={Autoimmunity},
  year={2001},
  volume={34 4},
  pages={
          247-64
        }
}
We previously reported serum cytokines in a group of long term non-progressors to Type 1 diabetes; this reactivity detected in ELISA is now identified as heterophile antibody in some sera. Here, we characterize heterophile antibody activity. A 14 kDa-polypeptide from heterophile antibody containing serum bound to an anti-IL-4 column, but IL-4 was not detected by Western blot or by MS/MS sequencing. However, in 2/13 heterophile antibody positive sera, T-cell growth was potentiated and was… CONTINUE READING
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