Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy.

@article{Zeevi2010HeteromultimericTC,
  title={Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy.},
  author={David A. Zeevi and Shaya Lev and Ayala Frumkin and Baruch Minke and Gideon Bach},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 18},
  pages={3112-24}
}
The mucolipin (TRPML) subfamily of transient receptor potential (TRP) cation channels consists of three members that play various roles in the regulation of membrane and protein sorting along endo-lysosomal pathways. Loss-of-function mutations in TRPML1 cause the neurodegenerative lysosomal storage disorder, mucolipidosis type IV (MLIV), whereas a gain-of… CONTINUE READING