Heteromeric amino acid transporters: biochemistry, genetics, and physiology.

@article{Chillarn2001HeteromericAA,
  title={Heteromeric amino acid transporters: biochemistry, genetics, and physiology.},
  author={Josep Chillar{\'o}n and R Roca and Arnubio Valencia and Antonio Zorzano and Manuel Palac{\'i}n},
  journal={American journal of physiology. Renal physiology},
  year={2001},
  volume={281 6},
  pages={
          F995-1018
        }
}
The heteromeric amino acid transporters (HATs) are composed of two polypeptides: a heavy subunit (HSHAT) and a light subunit (LSHAT) linked by a disulfide bridge. HSHATs are N-glycosylated type II membrane glycoproteins, whereas LSHATs are nonglycosylated polytopic membrane proteins. The HSHATs have been known since 1992, and the LSHATs have been described in the last three years. HATs represent several of the classic mammalian amino acid transport systems (e.g., L isoforms, y(+)L isoforms, asc… CONTINUE READING

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