Heterologous sensitization of recombinant adenylate cyclases by activation of D(2) dopamine receptors.

@article{Cumbay2001HeterologousSO,
  title={Heterologous sensitization of recombinant adenylate cyclases by activation of D(2) dopamine receptors.},
  author={Medhane G. Cumbay and Val J. Watts},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={297 3},
  pages={1201-9}
}
Persistent activation of Galpha(i/o)-coupled receptors results in an enhanced responsiveness of drug-stimulated adenylate cyclase activity through an unknown mechanism. This agonist-induced heterologous sensitization of drug-stimulated cyclic AMP accumulation has been proposed to be a mechanism by which cells adapt to prolonged Galpha(i/o) activation. Heterologous sensitization was examined in human embryonic kidney 293 cells stably expressing D(2L) dopamine receptors in combination with… CONTINUE READING