Heterologous prime-boost vaccination against tuberculosis with recombinant Sendai virus and DNA vaccines

@article{Hu2019HeterologousPV,
  title={Heterologous prime-boost vaccination against tuberculosis with recombinant Sendai virus and DNA vaccines},
  author={Zhidong Hu and Weimin Jiang and Ling Gu and Dan Qiao and Tsugumine Shu and Douglas Bruce Lowrie and Shuihua Lu and Xiao-Yong Fan},
  journal={Journal of Molecular Medicine},
  year={2019},
  volume={97},
  pages={1685 - 1694}
}
In an earlier study, a novel Sendai virus–vectored anti-tuberculosis vaccine encoding Ag85A and Ag85B (SeV85AB) was constructed and shown to elicit antigen-specific T cell responses and protection against Mycobacterium tuberculosis (Mtb) infection in a murine model. In this study, we evaluate whether the immune responses induced by this novel vaccine might be elevated by a recombinant DNA vaccine expressing the same antigen in a heterologous prime-boost vaccination strategy. The results showed… 
4 Citations
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