Heterologous human immunodeficiency virus type 1 priming-boosting immunization strategies involving replication-defective adenovirus and poxvirus vaccine vectors.

@article{Casimiro2004HeterologousHI,
  title={Heterologous human immunodeficiency virus type 1 priming-boosting immunization strategies involving replication-defective adenovirus and poxvirus vaccine vectors.},
  author={Danilo R. Casimiro and Andrew J. Bett and Tong-Ming Fu and Michael C.R. Davies and Aimin Tang and Keith A A Wilson and Minchun Chen and Romnie S. Long and Troy W McKelvey and Michael A Chastain and Sanjay Gurunathan and Jim Tartaglia and Emilio A. Emini and John Shiver},
  journal={Journal of virology},
  year={2004},
  volume={78 20},
  pages={11434-8}
}
We compared the human immunodeficiency virus type 1 (HIV-1)-specific cellular immune responses elicited in nonhuman primates by HIV-1 gag-expressing replication-defective adenovirus serotype 5 (Ad5) or poxvirus vectors, used either alone or in combination with each other. The responses arising from a heterologous Ad5 priming-poxvirus boosting regimen were significantly greater than those elicited by homologous regimens with the individual vectors or by a heterologous poxvirus priming-Ad5… CONTINUE READING

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