Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8.

@article{Liu2020HeterologousEO,
  title={Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8.},
  author={Wei-ning Liu and Vinay Gopal Jannu and Zhiwen Liu and Qingbo Zhang and Xiao-dong Jiang and Liang Ma and Wenjun Zhang and Changsheng Zhang and Yiguang Zhu},
  journal={Organic & biomolecular chemistry},
  year={2020}
}
Trichostatins are potent inhibitors of histone deacetylase (HDAC). In this work, a new trichostatin derivative isotrichostatin RK (1) and five known compounds trichostatin RK (2), JBIR-111 (3), 9179B (4), trichostatic acid (5) and trichostatin A (6) were isolated from marine-derived Streptomyces sp. SCSIO 40028. The biosynthetic gene cluster (tsnB) for trichostatins was identified from Streptomyces sp. SCSIO 40028 and validated by heterologous expression in Streptomyces lividans TK64. N… Expand

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