Heterologous expression of the naphthocyclinone hydroxylase gene from Streptomyces arenae for production of novel hybrid polyketides


Streptomyces arenae produces at least four different isochromanequinone antibiotics, the naphthocyclinones, of which the β- and γ-form are active against Gram-positive bacteria. The naphthocyclinone biosynthesis gene cluster was isolated from Streptomyces arenae DSM 40737 and by sequence analysis the minimal polyketide synthase genes and several genes… (More)
DOI: 10.1023/A:1012037329949


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