Heterologous expression of the naphthocyclinone hydroxylase gene from Streptomyces arenae for production of novel hybrid polyketides

Abstract

Streptomyces arenae produces at least four different isochromanequinone antibiotics, the naphthocyclinones, of which the β- and γ-form are active against Gram-positive bacteria. The naphthocyclinone biosynthesis gene cluster was isolated from Streptomyces arenae DSM 40737 and by sequence analysis the minimal polyketide synthase genes and several genes… (More)
DOI: 10.1023/A:1012037329949

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