Heterologous expression of carcinoembryonic antigen in Lactococcus lactis via LcsB-mediated surface displaying system for oral vaccine development.

@article{Zhang2016HeterologousEO,
  title={Heterologous expression of carcinoembryonic antigen in Lactococcus lactis via LcsB-mediated surface displaying system for oral vaccine development.},
  author={Xiaowei Zhang and Shumin Hu and X Du and Tiejun Li and Lanlan Han and Jian Kong},
  journal={Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi},
  year={2016},
  volume={49 6},
  pages={851-858}
}
BACKGROUND/PURPOSE Carcinoembryonic antigen (CEA) is an attractive target for immunotherapy because it is expressed minimally in normal tissue, but is overexpressed in a wide variety of malignant epithelial tissues. Lactic acid bacteria (LABs), widely used in food processes, are attractive candidates for oral vaccination. Thus, we examined whether LABs could be used as a live vaccine vector to deliver CEA antigen. METHODS CEA was cloned into an Escherichia coli/Lactococcus lactis shuttle… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Evaluation of oral immunization with recombinant avian influenza ession of carcinoembryonic antigen in Lactococcus lactis via LcsBurnal of Microbiology, Immunology and Infection

  • H Lei, Z Sheng, Q Ding, J Chen, X Wei, DMK Lam
  • 2011
3 Excerpts

Similar Papers

Loading similar papers…