Heterologous expression of G-protein-coupled receptors.

@article{Tate1996HeterologousEO,
  title={Heterologous expression of G-protein-coupled receptors.},
  author={Christopher G. Tate and Reinhard Grisshammer},
  journal={Trends in biotechnology},
  year={1996},
  volume={14 11},
  pages={426-30}
}
G-protein-coupled receptors (GPCRs) are integral membrane proteins of great pharmacological importance owing to their central role in the regulation of cellular responses to external stimuli. Heterologous expression systems have been used to explore ligand binding, G protein and effector coupling, and structural aspects of the receptors. GPCRs can be expressed in a functional form in all expression systems, but with varying degrees of success because of differences in receptor and host cell… CONTINUE READING

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