Heterologous desensitization of the rat tail artery contraction and inositol phosphate accumulation after in vitro exposure to phenylephrine is mediated by decreased levels of Galphaq and Galphai.

@article{Seasholtz1997HeterologousDO,
  title={Heterologous desensitization of the rat tail artery contraction and inositol phosphate accumulation after in vitro exposure to phenylephrine is mediated by decreased levels of Galphaq and Galphai.},
  author={Tammy M. Seasholtz and Hakan Gurdal and Huaixing Wang and Guoping Cai and Mark D. Johnson and Eitan Friedman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={283 2},
  pages={925-31}
}
Desensitization of alpha-1 adrenoceptor (alpha1AR)-mediated responses in aortic smooth muscle after exposure to catecholamines or alpha1AR agonists has been widely demonstrated. To determine whether exposure to an alpha1AR agonist results in desensitization of alpha1AR-mediated responses in a resistance artery, rat tail artery rings were exposed to 7.5 or 75 microM phenylephrine (PE) for 22 hr in vitro. Norepinephrine-stimulated contraction was significantly reduced in PE-exposed tail artery… CONTINUE READING

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