Heterologous Expression of the Biosynthetic Gene Cluster for Verticilactam and Identification of Analogues.

  title={Heterologous Expression of the Biosynthetic Gene Cluster for Verticilactam and Identification of Analogues.},
  author={Toshihiko Nogawa and A Terai and Keita Amagai and Junko Hashimoto and Yushi Futamura and Akiko Okano and Manabu Fujie and Nori Satoh and Haruo Ikeda and Kazuo Shin‐ya and Hiroyuki Osada and Shunji Takahashi},
  journal={Journal of natural products},
Verticilactam and the new geometric isomers, verticilactams B and C, were produced by heterologous expression of the biosynthetic gene cluster for verticilactam using the Streptomyces avermitilis SUKA17 strain. Only verticilactam, a compound with a characteristic β-ketoamide unit within a 16-membered polyketide macrolactam conjugated with an octalin skeleton, had been previously reported having been isolated from Streptomyces spiroverticillatus JC-8444. In this report, minor verticilactam… 
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