Heterogenous mismatch-repair status in colorectal cancer

  title={Heterogenous mismatch-repair status in colorectal cancer},
  author={Patrick Joost and Nynke Veurink and Susanne Holck and Louise Laurberg Klarskov and Anders Bo Bojesen and Maria Harbo and Bo Baldetorp and Eva Rambech and Mef Nilbert},
  booktitle={Diagnostic pathology},
BACKGROUND Immunohistochemical staining for mismatch repair proteins is efficient and widely used to identify mismatch repair defective tumors. The tumors typically show uniform and widespread loss of MMR protein staining. We identified and characterized colorectal cancers with alternative, heterogenous mismatch repair protein staining in order to delineate… CONTINUE READING