Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells.

@article{Berberoglu2014HeterogeneouslyEF,
  title={Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells.},
  author={Michael A Berberoglu and Zhiqiang Dong and Guangnan Li and Jiashun Zheng and Luz del Carmen G Trejo Martinez and Jisong Peng and Mahendra Wagle and Brian Reichholf and Claudia K Petritsch and Hao Li and Samuel J Pleasure and Su Guo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 42},
  pages={13911-23}
}
Balancing quiescence, self-renewal, and differentiation in adult stem cells is critical for tissue homeostasis. The underlying mechanisms, however, remain incompletely understood. Here we identify Fezf2 as a novel regulator of fate balance in adult zebrafish dorsal telencephalic neural stem cells (NSCs). Transgenic reporters show intermingled fezf2-GFP(hi) quiescent and fezf2-GFP(lo) proliferative NSCs. Constitutive or conditional impairment of fezf2 activity demonstrates its requirement for… CONTINUE READING
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