Heterogeneous transforming growth factor (TGF)-beta unresponsiveness and loss of TGF-beta receptor type II expression caused by histone deacetylation in lung cancer cell lines.

@article{Osada2001HeterogeneousTG,
  title={Heterogeneous transforming growth factor (TGF)-beta unresponsiveness and loss of TGF-beta receptor type II expression caused by histone deacetylation in lung cancer cell lines.},
  author={Hirotaka Osada and Yoshio Tatematsu and Akira Masuda and Toshiko Saito and Masanori Sugiyama and Kiyoshi Yanagisawa and Takashi Takahashi},
  journal={Cancer research},
  year={2001},
  volume={61 22},
  pages={8331-9}
}
Transforming growth factor (TGF)-beta strongly inhibits epithelial cell proliferation. Alterations of TGF-beta signaling are thought to play a role in tumorigenesis. We show in the present study that most lung cancer cell lines have lost the growth-inhibitory response to TGF-beta signal, and that those with TGF-beta unresponsiveness can be divided into two major groups, TGF-beta type II receptor (TGFbetaRII)(+)/Smad7(+) and TGFbetaRII(-)/Smad7(-), suggesting the heterogeneous mechanisms… CONTINUE READING

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