Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control.

@article{Matthews2006HeterogeneousSO,
  title={Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control.},
  author={Louise Matthews and J. Chris Low and David L. Gally and Michael C. Pearce and Dominic Mellor and J. A. P. Heesterbeek and Margo E. Chase-Topping and Stuart W. Naylor and Darren J Shaw and Stuart W. J. Reid and George J. Gunn and Mark E. J. Woolhouse},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 3},
  pages={547-52}
}
Identification of the relative importance of within- and between-host variability in infectiousness and the impact of these heterogeneities on the transmission dynamics of infectious agents can enable efficient targeting of control measures. Cattle, a major reservoir host for the zoonotic pathogen Escherichia coli O157, are known to exhibit a high degree of heterogeneity in bacterial shedding densities. By relating bacterial count to infectiousness and fitting dynamic epidemiological models to… CONTINUE READING