Heterogeneous response of antimitochondrial autoantibodies and bile duct apical staining monoclonal antibodies to pyruvate dehydrogenase complex E2: the molecule versus the mimic.

@article{Migliaccio2001HeterogeneousRO,
  title={Heterogeneous response of antimitochondrial autoantibodies and bile duct apical staining monoclonal antibodies to pyruvate dehydrogenase complex E2: the molecule versus the mimic.},
  author={Christopher Migliaccio and Judy Van de Water and Aftab A Ansari and Marshall M. Kaplan and Ross L. Coppel and Kit Sang Lam and R K Thompson and Freida Stevenson and M Eric Gershwin},
  journal={Hepatology},
  year={2001},
  volume={33 4},
  pages={792-801}
}
The 2-oxo-acid dehydrogenase complexes and, in particular, the E2 component of the pyruvate dehydrogenase complex (PDC) are the target of antimitochondrial antibodies (AMA). More than 95% of primary biliary cirrhosis (PBC) patients have detectable levels of autoantibodies to PDC-E2 and in general these react with a region of the molecule that contains the… CONTINUE READING