Heterogeneous requirement of NGF for sympathetic target innervation in vivo.

  title={Heterogeneous requirement of NGF for sympathetic target innervation in vivo.},
  author={Natalia O. Glebova and David D Ginty},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={24 3},
The neurotrophin nerve growth factor (NGF) plays a crucial role in the development of the sympathetic nervous system. In addition to being required for sympathetic neuron survival in vivo and in vitro, NGF has been shown to mediate axon growth in vitro. The role of NGF in sympathetic axon growth in vivo, however, is not clear because of its requirement for survival. This requirement can be circumvented by a concomitant deletion of Bax, a pro-apoptotic Bcl-2 family member, thus allowing an… CONTINUE READING
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