Heterogeneous nuclear ribonucleoproteins F and K mediate insulin inhibition of renal angiotensinogen gene expression and prevention of hypertension and kidney injury in diabetic mice

@article{Abdo2013HeterogeneousNR,
  title={Heterogeneous nuclear ribonucleoproteins F and K mediate insulin inhibition of renal angiotensinogen gene expression and prevention of hypertension and kidney injury in diabetic mice},
  author={Shaaban Abdo and C.-S. Lo and Isabelle Ch{\'e}nier and Anastasia Shamsuyarova and J{\'a}nos G. Filep and Julie R. Ingelfinger and S.-L. Zhang and John S. D. Chan},
  journal={Diabetologia},
  year={2013},
  volume={56},
  pages={1649-1660}
}
We investigated whether heterogeneous nuclear ribonucleoproteins F and K (hnRNP F, hnRNP K) mediate insulin inhibition of renal Agt expression and prevention of hypertension and kidney injury in an Akita mouse model of type 1 diabetes. Adult male Akita mice (12 weeks old) were treated with insulin implants and killed at week 16. Untreated non-Akita littermates served as controls. The effects of insulin on blood glucose, systolic BP (SBP), renal proximal tubular cell (RPTC) gene expression and… CONTINUE READING