Heterogeneous nuclear ribonucleoproteins: role in RNA splicing.

  title={Heterogeneous nuclear ribonucleoproteins: role in RNA splicing.},
  author={Yang Do Choi and Paula J. Grabowski and Phillip A. Sharp and Gideon Dreyfuss},
  volume={231 4745},
Splicing in vitro of a messenger RNA (mRNA) precursor (pre-mRNA) is inhibited by a monoclonal antibody to the C proteins (anti-C) of the heterogeneous nuclear RNA (hnRNA)-ribonucleoprotein (hnRNP) particles. This antibody, 4F4, inhibits an early step of the reaction: cleavage at the 3' end of the upstream exon and the formation of the intron lariat. In contrast, boiled 4F4, or a different monoclonal antibody (designated 2B12) to the C proteins, or antibodies to other hnRNP proteins (120 and 68… CONTINUE READING


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