Heterogeneous nuclear ribonucleoprotein K contributes to angiotensin II stimulation of vascular endothelial growth factor mRNA translation.

@article{Fliers2007HeterogeneousNR,
  title={Heterogeneous nuclear ribonucleoprotein K contributes to angiotensin II stimulation of vascular endothelial growth factor mRNA translation.},
  author={Denis F{\'e}liers and M D Lee and Goutam Ghosh-Choudhury and Karol Bomsztyk and Balakuntalam S Kasinath},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 2},
  pages={F607-15}
}
ANG II rapidly increases VEGF synthesis in proximal tubular epithelial cells through mRNA translation. The role of heterogeneous nuclear ribonucleoprotein K (hnRNP K) in ANG II regulation of VEGF mRNA translation initiation was examined. ANG II activated hnRNP K as judged by binding to poly(C)- and poly(U)-agarose. ANG II increased hnRNP K binding to VEGF mRNA at the same time as it stimulated its translation, suggesting that hnRNP K contributes to VEGF mRNA translation. Inhibition of hnRNP K… CONTINUE READING
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