Heterogeneous nuclear ribonucleoprotein K is a transcription factor.

  title={Heterogeneous nuclear ribonucleoprotein K is a transcription factor.},
  author={Emil F. Michelotti and Gregory Alexander Michelotti and Andr{\'e} Aronsohn and David Levens},
  journal={Molecular and cellular biology},
  volume={16 5},
The CT element is a positively acting homopyrimidine tract upstream of the c-myc gene to which the well-characterized transcription factor Spl and heterogeneous nuclear ribonucleoprotein (hnRNP) K, a less well-characterized protein associated with hnRNP complexes, have previously been shown to bind. The present work demonstrates that both of these molecules contribute to CT element-activated transcription in vitro. The pyrimidine-rich strand of the CT element both bound to hnRNP K and… CONTINUE READING


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