Heterogeneous nuclear ribonucleoprotein C1/C2 controls the metastatic potential of glioblastoma by regulating PDCD4.

@article{Park2012HeterogeneousNR,
  title={Heterogeneous nuclear ribonucleoprotein C1/C2 controls the metastatic potential of glioblastoma by regulating PDCD4.},
  author={Young Mi Park and Su Jin Hwang and Kiyoshi Masuda and Kyung-Min Choi and Mi-Ran Jeong and Do-Hyun Nam and Myriam Gorospe and Hyeon Ho Kim},
  journal={Molecular and cellular biology},
  year={2012},
  volume={32 20},
  pages={4237-44}
}
MicroRNAs (miRNAs) have been implicated in the pathogenesis and progression of brain tumors. miR-21 is one of the most highly overexpressed miRNAs in glioblastoma multiforme (GBM), and its level of expression correlates with the tumor grade. Programmed cell death 4 (PDCD4) is a well-known miR-21 target and is frequently downregulated in glioblastomas in accordance with increased miR-21 expression. Downregulation of miR-21 or overexpression of PDCD4 can inhibit metastasis. Here, we investigate… CONTINUE READING
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