Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region.

@article{Mahajan2005HeterogeneousNR,
  title={Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region.},
  author={Milind C. Mahajan and Geeta J Narlikar and Gokul Boyapaty and Robert E. Kingston and Sherman Morton Weissman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 42},
  pages={15012-7}
}
Locus control regions (LCRs) are regulatory DNA sequences that are situated many kilobases away from their cognate promoters. LCRs protect transgenes from position effect variegation and heterochromatinization and also promote copy-number dependence of the levels of transgene expression. In this work, we describe the biochemical purification of a previously undescribed LCR-associated remodeling complex (LARC) that consists of heterogeneous nuclear ribonucleoprotein C1/C2, nucleosome remodeling… CONTINUE READING

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