Heterogeneous nuclear ribonucleoprotein A1 catalyzes RNA.RNA annealing.

  title={Heterogeneous nuclear ribonucleoprotein A1 catalyzes RNA.RNA annealing.},
  author={Stephen H. Munroe and Xiao Feng Dong},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={89 3},
Within the nucleus, pre-mRNA molecules are complexed with a set of proteins to form heterogeneous nuclear ribonucleoprotein complexes. A1, an abundant RNA binding protein present in these complexes, has been shown to bind selectively to single-stranded RNAs and destabilize base-pairing interactions. In this study.A1 is shown to promote the rate of annealing of complementary RNA strands greater than 300-fold under a wide range of salt concentration and temperature. Maximal annealing is observed… CONTINUE READING