Heterogeneous neurocytotoxic antibodies in systemic lupus erythematosus.

  title={Heterogeneous neurocytotoxic antibodies in systemic lupus erythematosus.},
  author={Harry G. Bluestein},
  journal={Clinical and experimental immunology},
  volume={35 2},
Sera from eighteen patients with systemic lupus erythematosus (SLE) were tested for cytotoxic antibody to three neuronal and two glial continuous cell lines of human origin. Eighty per cent (fifteen out of eighteen) of the sera were cytotoxic to at least one of the cell lines, but only seven sera were active against all five lines. Three sera had anti-neuronal but not anti-glial reactivity. No sera were gliocytotoxic without neurocytotoxicity. Three SLE sera with relatively strong cytotoxicity… CONTINUE READING

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