Heterogeneous kinetic properties of acetylcholine receptor channels in Xenopus myocytes.

We have used the cell-attached patch-clamp technique to examine the kinetic and conductance properties of acetylcholine receptor channel currents in cultured Xenopus myocytes. At high agonist concentrations (5-100 microM) the currents occurred in bursts of openings. The probability that a channel existed in an ion-conducting conformation during a burst (Po… CONTINUE READING