Heterogeneous gene methylation patterns among pre-invasive and cancerous lesions of the prostate: a histopathologic study of whole mount prostate specimens.

@article{Woodson2004HeterogeneousGM,
  title={Heterogeneous gene methylation patterns among pre-invasive and cancerous lesions of the prostate: a histopathologic study of whole mount prostate specimens.},
  author={Karen G Woodson and J. F. Gillespie and Jeffrey W. Hanson and Mike R. Emmert-Buck and John M Phillips and W. Marston Linehan and Joseph A. Tangrea},
  journal={The Prostate},
  year={2004},
  volume={60 1},
  pages={25-31}
}
BACKGROUND Gene methylation may contribute to prostate carcinogenesis through the silencing of gene transcription. We report on the methylation status of several genes shown to be silenced at different stages of progression using whole mount prostate specimens and laser capture microdissection. This is the first study to evaluate gene methylation patterns across multiple pre-cancerous and invasive cancer foci from the same prostate gland. METHODS Real-time PCR was used to evaluate methylation… CONTINUE READING

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