Heterogeneous expression of claudin-4 in human colorectal cancer: decreased claudin-4 expression at the invasive front correlates cancer invasion and metastasis.

@article{Ueda2007HeterogeneousEO,
  title={Heterogeneous expression of claudin-4 in human colorectal cancer: decreased claudin-4 expression at the invasive front correlates cancer invasion and metastasis.},
  author={Junya Ueda and Shuho Semba and Hideki Tachibana Chiba and Norimasa Sawada and Yasushi Seo and Masato Kasuga and Hiroshi Yokozaki},
  journal={Pathobiology : journal of immunopathology, molecular and cellular biology},
  year={2007},
  volume={74 1},
  pages={
          32-41
        }
}
OBJECTIVE Claudin-4 plays a key role in constructing the tight junction (TJ), and altered claudin-4 expression has been documented in various human malignancies; however, little is known about the biological significance of claudin-4 in colorectal cancers (CRCs). The aim of this study is to investigate the significance of claudin-4 expression in CRC and its association with clinicopathological factors. METHODS The levels of claudin-4 expression in a total of 129 CRCs and 44 metastatic tumors… CONTINUE READING

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