Heterogeneous expression of cell-surface antigens in normal epithelia and their tumours, revealed by monoclonal antibodies.

@article{Edwards1985HeterogeneousEO,
  title={Heterogeneous expression of cell-surface antigens in normal epithelia and their tumours, revealed by monoclonal antibodies.},
  author={Paul A. Edwards},
  journal={British Journal of Cancer},
  year={1985},
  volume={51},
  pages={149 - 160}
}
Most monoclonal antibodies that have been raised to human epithelial tumours bind to only some of the cells in a tumour, showing that tumour cells are very heterogeneous in their expression of antigens. Normal epithelia show the same heterogeneity of antigen expression, as also do cell lines and clones of epithelial cells in culture. It is not related to… CONTINUE READING