Heterogeneous effect of flavonoids on K+ loss and lipid peroxidation induced by oxygen-free radicals in human red cells.

@article{MaridonneauParini1986HeterogeneousEO,
  title={Heterogeneous effect of flavonoids on K+ loss and lipid peroxidation induced by oxygen-free radicals in human red cells.},
  author={Isabelle Maridonneau-Parini and Pierre G. Braquet and Ricardo P. Garay},
  journal={Pharmacological research communications},
  year={1986},
  volume={18 1},
  pages={61-72}
}
Treatment of fresh erythrocytes with phenazine methosulfate, an intracellular generator of oxygen-free radicals, and diethyldithiocarbamate an inhibitor of superoxide dismutase results in membrane damage consisting in lipid peroxidation and increase in passive K+ permeability. Various flavonoids which have previously been reported to act as oxygen-free radical scavengers were tested on this erythrocyte model. Surprisingly, flavonoids did not exhibit the same effect on the oxygen free radical… CONTINUE READING