Heterogeneous cardiac proteasomes: mandated by diverse substrates?


Proteasome biology has taken central stage in cardiac physiology and pathophysiology. The molecular heterogeneity of proteasome subpopulations supports the specificity of proteasome function to degrade diverse substrate repertoires. Unveiling the dynamics of proteasome function should inspire new therapeutic strategies for combating cardiac disease. 
DOI: 10.1152/physiol.00039.2010


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