Heterogeneous bacterial persisters and engineering approaches to eliminate them.

@article{Allison2011HeterogeneousBP,
  title={Heterogeneous bacterial persisters and engineering approaches to eliminate them.},
  author={Kyle R. Allison and Mark P. Brynildsen and James J. Collins},
  journal={Current opinion in microbiology},
  year={2011},
  volume={14 5},
  pages={593-8}
}
Bacterial persistence is a state in which a subpopulation of cells (persisters) survives antibiotic treatment, and has been implicated in the tolerance of clinical infections and the recalcitrance of biofilms. There has been a renewed interest in the role of bacterial persisters in treatment failure in light of a wealth of recent findings. Here we review recent laboratory studies of bacterial persistence. Further, we pose the hypothesis that each bacterial population may contain a diverse… CONTINUE READING

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