Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's disease.

@article{Bartzokis2004HeterogeneousAB,
  title={Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's disease.},
  author={George Bartzokis and David L. Sultzer and P. H. Lu and Keith H. Nuechterlein and Jim Mintz and Jeffrey L. Cummings},
  journal={Neurobiology of aging},
  year={2004},
  volume={25 7},
  pages={843-51}
}
Human and non-human primate data suggest that the structural integrity of myelin sheaths deteriorates during normal aging, especially in the late-myelinating association regions and may result in "disconnection" of widely distributed neural networks. Magnetic resonance imaging (MRI) was used to assess the heterogeneity of this process and its impact on brain aging and Alzheimer's disease (AD) by evaluating early- and later-myelinating regions of the corpus callosum, the splenium (Scc) and genu… CONTINUE READING
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