Heterogeneous SWI/SNF Chromatin Remodeling Complexes Promote Expression of Microphthalmia —Associated Transcription Factor Target Genes in Melanoma

@inproceedings{Keenen2010HeterogeneousSC,
  title={Heterogeneous SWI/SNF Chromatin Remodeling Complexes Promote Expression of Microphthalmia —Associated Transcription Factor Target Genes in Melanoma},
  author={Bridget Keenen and Huiling Qi and S. V. Saladi and Melissa E Yeung and I. L. de la Serna},
  booktitle={Oncogene},
  year={2010}
}
The microphthalmia-associated transcription factor (MITF) promotes melanocyte differentiation and cell-cycle arrest. Paradoxically, MITF also promotes melanoma survival and proliferation, acting like a lineage survival oncogene. Thus, it is critically important to understand the mechanisms that regulate MITF activity in melanoma cells. SWI/SNF chromatin remodeling enzymes are multiprotein complexes composed of one of two related ATPases, BRG1 or BRM, and 9–12-associated factors (BAFs). We… CONTINUE READING
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