Heterogeneous MHC II restriction pattern of autoreactive desmoglein 3 specific T cell responses in pemphigus vulgaris patients and normals.

@article{Hertl1998HeterogeneousMI,
  title={Heterogeneous MHC II restriction pattern of autoreactive desmoglein 3 specific T cell responses in pemphigus vulgaris patients and normals.},
  author={Dr. M. S. Hertl and Robert W. Karr and Masayuki Amagai and Stephen Ira Katz},
  journal={The Journal of investigative dermatology},
  year={1998},
  volume={110 4},
  pages={
          388-92
        }
}
Pemphigus vulgaris is a life threatening bullous autoimmune disease of the skin mediated by autoantibodies against desmoglein 3 (Dsg3) on epidermal keratinocytes. Pemphigus vulgaris patients exhibit T cell responses against Dsg3 that may serve as a target to modulate the production of pathogenic autoantibodies. Healthy carriers of major histocompatibility complex class II alleles identical or similar to those that are highly prevalent in pemphigus vulgaris, namely DRbeta1*0402 and DRbeta1*1401… CONTINUE READING
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